Assignment, Health sciences and medicine biostatestics

This assignment has 4 questions and it will be marked out of 35. It is worth 35% of the total marks for Biostatistics B. It covers the material in modules S7, S8 and S9. It is assumed that you have a clear understanding of the content of these modules.

Question 1 – 3 marks

In a study of intra-observer variability in the assessment of cervical smears, 3341 slides were screened for the presence or absence of abnormal squamous cells. Each slide was screened by a particular observer and then re-screened six months later by the same observer. The results of this study are shown in Table 1.1 below.

Table 1.1: Cross tabulation of the results of the first and second screening

		Second screening
		Present	Absent
First screening	Present	1764	498
	Absent	412	667

a)       Do these data support the null hypothesis that there is no association between time of screening and diagnosis? Briefly explain by carrying out an appropriate test.  

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